Updates
Dendritic Cell Biology
Understanding the role of Nuclear receptor co-repressors, Zinc finger TFs, Nuclear receptor co-regulators in Cd8a+ dendritic cells.
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Genomics
Understanding the underlying mechanism of adaptive immune response using Next Generation Sequencing technology and bioinformatics.
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Tools
Our lab has recently developed BedSect, a webserver application for co-binding event determination. A preprint version is available at Biorxiv....
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Dendritic cells (DCs) are specialized antigen-presenting cells that have to translate the pathogen encounter into the priming of appropriate T cell mediated immune responses. Together with other cells of the innate immune system, DCs induce the development of various different types of T cell responses designed to clear a specific pathogen and/or avoid immune pathology. These responses are mediated by diverse CD4+ T cell subsets, including Th1, Th2, Th17 and regulatory T (Treg) cells.
There is very little information about how DCs interpret and integrate the multiple pathogen signals to which they are exposed, thereby enabling them to ensure appropriate education of the responding T cells. This decision is decisive because it determines the balance between recovery and chronic disease or death. Therefore, the central aim of the lab is to employ integrative genomics approach to decipher the molecular mechanisms underlying
(i) immune response control in DCs thereby controlling the development/differentiation of T cells.
(ii) develop methods to immuno-modulate DC immune responses to modulate T cell speciation/differentiation.